Yintoni i-eosinophilic gastroenteritis?

I-Eosinophilic gastroenteritis (EG) yimeko enqabileyo echaphazela i-gastrointestinal tract, ngakumbi isisu kunye namathumbu amancinci. Iimpawu eziqhelekileyo zesimo ziquka urhudo, iintlungu zesisu, kunye nesicaphucaphu.

Isifo se-eosinophilic gastrointestinal ngamanye amaxesha sibizwa ngokuba yi-"eosinophilic gastritis" xa isisu sichaphazelekayo, okanye "eosinophilic esophagitis" xa iimpawu zichaphazela ikakhulu ummizo.

"I-Eosinophilic" ligama elisetyenziselwa ukuchaza ubukho be "eosinophils", uhlobo lwegazi elimhlophe elidlala indima ebalulekileyo ekukhuseleni amajoni omzimba. Uninzi lwee-eosinophils lufumaneka emathunjini, kwisibeleko, kumongo wethambo, kumadlala amabele kunye nakwithishu ye-adipose, kwaye ngokuqhelekileyo zikhutshelwa egazini xa umzimba wasemzini - umzekelo, ibhaktiriya - ingena emzimbeni kwaye ibangela ukusabela komzimba.

Xa umntu ephethwe yi-eosinophilic gastroenteritis, ii-eosinophils zikhutshwa ngamanani awandayo kwizicubu zazo. Ezi eosinophils zingena kumzila wesisu, okubangela ukudumba.

Imeko ichaphazela iindawo ezininzi zendlela yokugaya kwaye ibangela iimpawu ezahlukeneyo zesisu. Ngokuqhelekileyo ichaphazela isisu kunye namathumbu amancinci, kodwa ezinye iindawo zendlela yokugaya esezantsi zinokuchaphazeleka nazo.

Ngokungafaniyo nezinye izifo zendlela yokwetyisa - ezifana nesifo se-gastroesophageal reflux (GERD), esichaphazela malunga nesithathu sabemi behlabathi - i-eosinophilic gastroenteritis inqabile. Kuqikelelwa ukuba kukho iimeko ezingama-22-28 kubantu abayi-100,000 e-US.

Inokuchaphazela bobabini abantwana kunye nabantu abadala. Xa iqala ebusaneni, kukho ithuba elikhulu lokuba umntwana abe ne-gastroenteritis ephindaphindiweyo ekupheleni komntwana.

Imeko inokuchaphazela zonke iindidi ezintathu zodonga lwamathumbu: i-muscular layer, i-mucosal layer kunye ne-serosal layer. Igama elithile eosinophilic gastritis isetyenziselwa ukuchaza i-eosinophilic gastroenteritis echaphazela i-gastric mucosa (umphezulu wangaphakathi wesisu).

Yintoni ebangela i-eosinophilic gastroenteritis?

Izazinzulu azikaqondi ngokupheleleyo ukuba yintoni ebangela i-eosinophilic gastroenteritis. Inkqubela phambili yayo ekuhambeni kwexesha kubantu abachaphazelekayo ayibhalwanga kakuhle. Nangona kunjalo, uphando oluthile lubonisa ukuba ukusabela kwe-hypersensitivity kubangela imeko.

Ukusabela kwe-Hypersensitivity kwenzeka xa amajoni omzimba - ahlala ekhusela umzimba wakho - agqithise ngendlela enokuvelisa iziphumo ezinobungozi. Imizekelo ye-hypersensitivity reactions ibandakanya i-allergies kunye ne-autoimmunity.

I-allergies kuxa amajoni omzimba aphendula kakubi kwezinye iiarhente zokusingqongileyo ezingenabungozi ezifana intaka yezilwanyana, umungu kwaye ukutya. I-Autoimmunity kuxa umzimba usilela ukuqaphela iiseli zawo kunye nezicubu, ezibangela ukuba amajoni omzimba ahlasele iiseli ezisempilweni, izicubu kunye namalungu. Umzekelo we-autoimmunity luhlobo lwe-1 yeswekile, apho amajoni omzimba atshabalalisa iiseli ze-pancreatic ezivelisa i-insulin.

Malunga ne-50% yabantu abafunyaniswa benemeko nabo bane-hypersensitive okanye i-allergic conditions ezifana i-asthma, i-rhinitis kunye Eczema. Iingcali zenzululwazi zikholelwa ukuba iimpendulo ezibangelwa yi-allergic kunye nokuvuvukala okubangelwa kwezi meko zingabangela umonakalo kwi-intestinal barrier, kubangela ukungenwa kwee-eosinophils emathunjini.

Ezinye izifo zokugaya ezinokuthi zidityaniswe nale meko ziquka isifo se-celiac kunye ne-ulcerative colitis. Ngaphandle kwala makhonkco anokubakho, i-eosinophilic gastroenteritis inokwenzeka yodwa.

Kukho neemeko apho isigulane sihlaselwa yi-idiopathic eosinophilic gastroenteritis, apho kungaziwa imbangela yale meko.

Uphando olongezelelekileyo kusafuneka lwenziwe kwizizathu kunye nemiba yomngcipheko wale meko.

Ngaba i-eosinophilic gastroenteritis iyingozi?

I-Eosinophilic gastroenteritis inokubangela iingxaki ezinzulu ezifana nokugqobhoza kwamathumbu kunye nokuvaleka. Umntu onale meko unokuba neempawu ezingaqhelekanga nezinokumenza buthathaka. Nangona kunjalo, ukufa kwabantu kunqabile.

Iimpawu zeGastroenteritis

I-Eosinophilic gastroenteritis sisifo esingapheliyo. Malunga ne-80% yabantu abaphethwe sisifo baba neempawu iminyaka emininzi.

Iimpawu ziyahluka ngokuxhomekeka kwindawo echaphazelekayo kunye nobunzulu bempendulo yokuvuvukala kwamanqanaba odonga lwamathumbu.

Ngokomzekelo, i-eosinophilic gastritis (apho i-mucosa yesisu ichaphazeleka) inokubangela iimpawu ezifana ne-anemia, ukulahleka kwesisindo, ukuhlanza, intlungu yesisu kunye nohudo. Ukungena kwe-subserosal layer kunokubangela i-eosinophilic ascites, ngelixa ukungeniswa kwe-muscular layer yesisu kunokubangela ukuqina kunye nokuqina kweendonga zesisu kunye nokuphazamiseka kwe-pyloric.

Ezinye iimpawu ze-eosinophilic gastroenteritis ziquka:

  • Izitulo zegazi
  • I-Edema
  • Ingxaki yokuginya
  • Iintlungu zesifuba
  • Ukunyanzelisa
  • Ukuqhawula
  • I sizathu

Ngaba i-eosinophilic gastroenteritis iyanyangeka?

Ngokutsho kweCanadian Society of Intestinal Research, okwangoku akukho nyango lwe-eosinophilic gastrointestinal disease. Nangona kunjalo, ubungqina bubonise ukuba imeko inokulawulwa kwaye iimpawu zayo ziyancipha.

Olunye uphononongo lubonise izithembiso zonyango olunokwenzeka kunye nokhetho olusebenzayo lonyango lwe-eosinophilic gastroenteritis. Unyango lujolise ekuphuculeni i-histology ye-gastrointestinal tract (ukunciphisa inani le-eosinophils) kunye nokunciphisa iimpawu.

Indlela yokuvavanya i-eosinophilic gastroenteritis

Ngokudabukisayo, abantu abaninzi abanezifo ze-eosinophilic zesisu bahamba iminyaka ngaphandle kokufumana ukuxilongwa ngokuchanekileyo. Oku kungenxa yokuba ezinye izifo ezichaphazela umthambo wokugaya zibangela iimpawu ezifanayo. Isifo se-reflux ye-gastroesophageal, isifo se-celiac, i-ulcerative colitis kunye nesifo sikaCrohn zonke zinokuba neprofayili yeempawu ezifanayo kwi-eosinophilic gastroenteritis.

Ngenxa yesi sizathu, kubalulekile ukuba ungaqalisi unyango ngaphandle kokubonisana nodokotela wakho wentsapho okanye ingcali, ngokufanelekileyo i-gastroenterologist (ugqirha ojongene nokuxilongwa kunye nokunyanga izifo zesisu).

Okwangoku, olona vavanyo lubalulekileyo lokuxilonga izifo zesisu se-eosinophilic yi-endoscopic biopsy. Kolu vavanyo, ugqirha uya kuthatha iisampuli kumzila wakho wesisu. Iingcali ziya kuphonononga isampulu yakho yeempawu zesifo se-eosinophilic gastrointestinal ngokubala inani leeeosinophils. Ukungabikho kosulelo lwe-parasitic, inani eliphezulu le-eosinophil, kunye nobukho beempawu ezifanelekileyo kuya kukhomba kwi-eosinophilic gastroenteritis.

Ugqirha wosapho lwakho okanye ingcali isenokuthi kananjalo iyalele iimvavanyo zaselabhorethri, ezinje ngeisampulu zelindle, uvavanyo lwegazi kunye novavanyo lokuhlaba ulusu, ukukhupha ezinye iimeko.

impatho

Iindaba ezimnandi zezokuba i-eosinophilic gastroenteritis inokunyangwa kwaye ilawulwe. Unyango luyohluka ngokuxhomekeke kwinxalenye yendlela yokwetyisa echaphazelekayo kodwa ngokubanzi ibandakanya umxube wamayeza kunye notshintsho lokutya.

Amachiza

Iimpawu ze-flare-ups ziyakwazi ukulawulwa ngokufanelekileyo usebenzisa i-corticosteroids yomlomo, enika i-90% yokuphendula izinga. I-corticosteroids eqhelekileyo emiselweyo ziquka i-prednisolone, i-budesonide kunye ne-fluticasone. Enye yeempembelelo zokuthatha i-corticosteroids yomlomo yi-thrush yomlomo. Ugqirha wakho wosapho unokucebisa ukuba uhlambe umlomo wakho kwaye utshice emva kokusela ichiza lakho.

Ugqirha wakho wosapho okanye ingcali inokukumisela amanye amayeza afana nezinzisi zeeseli zemast (ezinciphisa iziphumo zeeseli ezithile zokhuselo lomzimba) kunye ne-antihistamines (ezinqanda iintshukumo zokudumba kwe-histamine).

Unyango lokutya

Unyango lokutya luye lwasetyenziselwa ukunyanga i-eosinophilic gastroenteritis. Nangona kunjalo, okwangoku abukho ubungqina obubambekayo bokuba unyango lokutya lusebenza ekunciphiseni ukubonakaliswa kwesi sifo.

Unyango lokutya lubandakanya ukuphelisa ukutya okuqhelekileyo okubangela ukungezwani komzimba. Oku kunokubandakanya ingqolowa, isoya, amaqanda, imveliso yobisi, intlanzi/iqokobhe kunye namandongomane/amandongomane. Ukutya okulungiselelwe ulawulo lwe-eosinophilic gastroenteritis kunokungabandakanyi amanye okanye onke la maqela okutya.

Ukuhlinzwa

Kwiimeko ezinqabileyo, utyando lunokufuneka. Oku kuqhelekile xa ezinye iindlela zonyango zingancedanga kulawulo lwesimo.

isishwankathelo

I-Eosinophilic gastroenteritis sisifo esinganyangekiyo esinqabileyo senkqubo yokwetyisa esinokubangela imingeni kwizigulana kunye noogqirha bazo. Oku kungenxa yokuba kukho izifundo ezimbalwa ngezizathu zayo, ukuxilongwa kunye nonyango.

Ngaphandle koku, i-eosinophilic gastroenteritis ayifane ibulale, kwaye unyango lwexesha elide lubonakalise ukuba lusebenza ekudambiseni iimpawu kunye nokuphucula umgangatho wobomi bubonke.

Ukuba awuyinyangi i-eosinophilic gastritis ngokufanelekileyo, inokukhokelela kwi-anemia, ukungondleki kunye nokukhula kakubi. Thetha nogqirha wakho ukuba ufumana iimpawu eziqhelekileyo ze-gastroenteritis engapheliyo. Ungaqhagamshelana ne-GAAPP okanye enye yayo imibutho yamalungu ukufumana iingcebiso.

Ucaphulo

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