Funda ngamayeza ebhayoloji

Yintoni amayeza ebhayoloji?

Amayeza amaninzi aveliswa kwilabhoratri kusetyenziswa inkqubo yeekhemikhali - ziimolekyuli ezincinci kwaye zijolise ekupheliseni iimpawu ozifumanayo, kodwa aziyinyangi eyona nto ibangela impilo yakho. Isakhiwo sabo silula kwaye sichongwe ngokulula. Amayeza ebhayoloji angena nzulu - aphatha inkxalabo yakho yezempilo ngokugxila kwiiseli ezithile, iiprotheni kunye neendlela. Zikhuliswa elabhoratri ukusuka kwizinto eziphilayo ezinjengabantu, izilwanyana okanye i-microorganisms. Ngamayeza amakhulu kwaye antsokothileyo aphambili kuphando lwamachiza. Amayeza amatsha e-Biological ahlala ephuhliswa.

Lingandenzela ntoni iyeza lebhayoloji?

Kwizigulana ezineemeko ezinjenge-asthma enzima, i-atopic dermatitis, i-nasal polyps, okanye i-urticaria engapheliyo, i-Biologicals "inokucima" iindawo ze-immune system ezinegalelo kakhulu ekudumbeni. Oku kukhokelela kwiimpawu ezincinci, ukuphuculwa komsebenzi, kwaye kaninzi kuphuculwe umgangatho wobomi.

Kwiziphazamiso ezifana ne-primary immunodeficiencies okanye i-angioedema yofuzo, iBiologicals inokubuyisela amaqhekeza angekhoyo amajoni omzimba okanye iphazamise iindlela ezisebenza ngokugqithisileyo. Nokuba imeko ithini na, iiBiologicals zisebenza kwiithagethi ezithile endaweni yokuthomalalisa amajoni omzimba ngokufana nendlela esebenza ngayo i-corticosteroids. 

Okukhona kujoliswe kuko, umngcipheko omncinci weziphumo ebezingalindelekanga zexesha elide.

Lunjani unyango ngamayeza ebhayoloji?

Amayeza ebhayoloji adla ngokusetyenziswa xa olunye unyango lungasebenzi kwaye ajolise kwiiseli ezithile ukuthintela ukuba iimpawu zingenzeki – awaneli nje ukunyanga iimpawu ukuthomalalisa ukungakhululeki. Iyeza linikezelwa ngenaliti, ngokuqhelekileyo kwiofisi kagqirha okanye ekliniki.

La mayeza akanikezeli ngokukhawuleza; kuthatha ixesha ukuba iziphumo zamayeza zivakale kwaye kunokubakho iziphumo ebezingalindelekanga zamayeza ahlukeneyo. Kwezinye iimeko, amayeza ebhayoloji angaphezu kwesinye anokufuna ukuzama ukufumana unyango olululo kwisigulana ngasinye.

Ngawaphi amayeza ebhayoloji asetyenziselwa ukwaliwa kunye nemiba yempilo yomoya?

(Nceda ujonge ukubona ukuba ngawaphi amayeza avunyiweyo kwilizwe lakho)

Kukho uluhlu olukhulayo lwamayeza ebhayoloji akhoyo ukuze asetyenziswe kwimiba yezempilo yokwaliwa kunye neyomoya. Abanye banokujolisa ngaphezulu kwemibandela yezempilo enye kwaye zidweliswe kudidi olungaphezulu kwesinye.

Apha ngezantsi kukho indlela yokusebenza yamayeza amaninzi avunyiweyo eBhayoloji (ukuchaza ulwazi kuxhomekeke kwilizwe ohlala kulo):

  • I-Benralizumab (Fasenra) - Isetyenziselwa ukuphatha i-asthma eosinophilic.
    • Ithagethi yonyango: I-IL-5 i-receptors ebandakanyekayo ekulawuleni i-eosinophils.
  • I-Tezepelumab-ekko (Tezspire) - Inyanga i-asthma enzima.
    • Ithagethi yonyango: I-TSLP, i-cytokine ephambili ye-epithelial.
  • I-Mepolizumab (i-Nucala) - Inyanga i-asthma ye-eosinophilic engalawulwa ngamanye amayeza e-asthma.
    • Ithagethi yonyango: Iprotheni ye-IL-5, i-cytokine ejongene nokulawula i-eosinophils.
  • I-Omalizumab (Xolair) – Inyanga i-asthma ye-aleji ephakathi ukuya-ebukhali. Kwakhona isetyenziselwa ukunyanga i-urticaria engapheliyo (i-hives).
    • Ithagethi yonyango: Ikhusela i-IgE ekubopheni i-IgE receptors kwiiseli zemast & basophils.
  • I-Dupilumab (i-Dupixent) -Iphatha ezimbini zemithombo ephambili ye-Type 2 ukuvuvukala ukunceda ukuphucula iimpawu ze-asthma 
    • Ithagethi yonyango: Iinjongo ze-IL-4 kunye ne-IL-13 ukubonakaliswa, ezimbini zabaqhubi abaphambili bendawo kunye ne-systemic uhlobo lwe-2 yokuvuvukala.
  • I-Reslizumab (Cinqair) – Isetyenziselwa ukunyanga isifo sombefu esiqatha.
    • Ithagethi yonyango: i-IL-5 receptors, iyanciphisa ukukhula okanye ukwanda kwee-eosinophils.
  • I-Dupilumab (i-Dupixent) - Iphatha i-atopic dermatitis ephakathi ukuya kwi-eczema (i-eczema) engaphenduli kakuhle kwezinye iindlela zonyango zonyango.
    • Ithagethi yonyango: i-antibody ebophelela kwi-IL-4 i-receptor alpha chain kwaye ivimba ukubonakaliswa kwee-cytokines eziphambili zokudumba, i-IL-4 kunye ne-IL-13.
  • Tralokinumab-ldrm – (Adbry) – Kunyango lwe-atopic dermatitis ebukhali.
    • Ithagethi yonyango: Ivimba ukubonakaliswa kwe-cytokine IL-13 evuthayo.
  • I-Omalizumab (Xolair) – Inyanga i-asthma ye-aleji ephakathi ukuya-ebukhali. Kwakhona isetyenziselwa ukunyanga i-urticaria engapheliyo (i-hives).
    • Ithagethi yonyango: Ikhusela i-IgE ekubopheni i-IgE receptors kwiiseli ze-mast kunye ne-basophil: iiseli zokuzivikela ezithintekayo kwimpendulo ye-allergies.
  • I-Quilizumab - Isetyenziselwa unyango lwe-asthma ye-allergen kunye ne-urticaria engapheliyo.
    • Ithagethi yonyango: I-IgE - ivimba impendulo ye-allergies.
  • I-Dupilumab (i-Dupixent) - Iphatha i-atopic dermatitis ephakathi ukuya kwi-eczema (i-eczema) engaphenduli kakuhle kwezinye iipilisi zonyango kunye neepolyps zekhala.
    • Ithagethi yonyango: I-IL-4 receptor alpha chain.
  • I-Mepolizumab (i-Nucala) - Kwizigulane ezine-asthma ye-eosinophilic ezingalawulwa ngamanye amayeza e-asthma. Ingasetyenziselwa ukunyanga i-rhinosinusitis engapheliyo ngeempumlo zempumlo (CRwNP).
  • Ithagethi yonyango: I-IL-5 i-receptors ebandakanyekayo ekulawuleni i-eosinophils.

Unyango lwe-HAE lubandakanya i-plasma-derived and recombinant C1-INH, iiprotheyini ezintsha eziphinda ziphinde zenziwe kunye ne-monoclonal antibodies (njenge-ecallantide, i-lanadelumab kunye ne-monoclonal antibodies evimba i-FXIIa) kunye neepeptides zokwenziwa kunye neemolekyuli ezincinci (njenge-iccatibant, BCX 7353 kunye ne-KVD). Iinketho zonyango zabantwana zisanda kwandiswa kwaye azibandakanyi kuphela i-pdC900-INH kodwa kunye ne-iccatibant.

  • I-Immunoglobulin subcutaneous (CutaQuig) - Inyanga abantu abadala kunye nabantwana abane-primary immunodeficiency (PI).
    • Eli liyeza liqulethe i-immunoglobulin G (IgG) enceda ukulwa nosulelo. Ifakwe phantsi kwesikhumba.
    • Zininzi iindlela zeli yeza ezinokunikwa nge-intravenously ngokunjalo.
  • I-Dupilumab (i-Dupixent) - Ivunyiwe kwi-EoE kwaye iphatha i-atopic dermatitis ephakathi ukuya kwi-eczema (i-eczema) engaphenduli kakuhle kwezinye iindlela zonyango zonyango.
    • Ithagethi yonyango: i-antibody ebophelela kwi-IL-4 i-receptor alpha chain kwaye ivimba ukubonakaliswa kwee-cytokines eziphambili zokudumba, i-IL-4 kunye ne-IL-13.
  • I-Omalizumab (Xolair) – Kungoku nje iphantsi kophando yi-FDA yokulawula ukwaliwa kokutya.

Ngaba akhona amayeza ebhayoloji eCOPD?

Siza kubona amayeza ebhayoloji amaninzi ephuhliswa lonke ixesha. Ngoku kukho iibhayoloji ezintandathu ezahlukeneyo ezifundwayo kwiSigaba sesi-III solingo kwiinkqubo zekliniki zeCOPD kwihlabathi jikelele. Zijonge ukuba zifumaneke kwingingqi yakho.

Ngawaphi amagama ekufuneka uyazi xa uthetha ngamayeza e-Biological?

Amagama abalulekileyo okanye amabinzana ekufuneka uyazi xa uxoxa ngamayeza ebhayoloji:

  • Imveliso yebhayoloji - esetyenziselwa ukuthintela kunye nokunyanga izifo kunye nemiba yezempilo. Zizintlobo ezahlukeneyo zeemveliso eziveliswa kwinto ephilayo (iiseli zomntu, iiseli zezilwanyana okanye i-microorganisms).
  • Iyeza le-Biosimilar - Ikopi efana kakhulu yeyeza le-biologic elinesenzo esifanayo kodwa iveliswe ngexabiso eliphantsi.
  • Iiseli- eyona yunithi incinci enokuthi iphile yodwa kwaye yenze izinto eziphilayo. “Iibhloko zokwakha” zezinto eziphilayo.
  • Inkqubo yemichiza – indlela yokuguqula ukwakheka kunye nokwakheka kwento enye ibe kwenye.
  • Eosinophils - uhlobo lweeseli ezikhusela umzimba ezinamasuntswana amancinci anee-enzymes ezikhutshwa ngexesha losulelo, ukuchasana nomzimba kunye ne-asthma.
  • Inkqubo yomzimba - uthungelwano oluntsonkothileyo lweeseli, izicubu okanye amalungu anceda umzimba ukulwa nosulelo kunye nezifo.
  • Into ephilayo -into ephilayo enesakhiwo esilungelelanisiweyo kwaye inokusabela kwi-stimuli, ivelise, ikhule, ilungele kwaye igcine ubomi.
  • Unyango – Ulawulo kunye nokhathalelo lwesigulane ukukhusela okanye ukulawula imeko yempilo.

Kuthekani ukuba ndinemiba emibini okanye ngaphezulu yezempilo enokuzuza kumayeza ebhayoloji?

Ngelixa amanye amayeza ebhayoloji enokunyanga ngaphezulu kwenkxalabo yezempilo enye, unokunyangwa ngendibaniselwano yamayeza ebhayoloji xa kukho imfuneko. Kubalulekile ukuthetha nogqirha wakho ngayo yonke imiba yakho yezempilo ukuze olona nyango lulodwa lukhethekileyo luphuhliselwe wena.

Amayeza ebhayoloji anyanga imiba ethile kwimithombo yawo - kwinqanaba leselula. Ukuba ubufuna ukunyanga umba ongaphezulu kwesinye, amayeza ebhayoloji angaphezu kwesinye anokumiselwa ngugqirha wakho ukuze aqinisekise ukukunceda ukunyanga zonke iimpawu zakho.

Ngaba amayeza ebhayoloji ayabiza?

Amayeza ebhayoloji ayabiza. Ngoba? Yinkqubo entsonkothileyo yokuvelisa la mayeza aphambili kwaye oko kubonakaliswa kwiindleko zamayeza. Iimveliso ziziphumo zophando olubanzi kunye nabakhuphisana abambalwa ngeli xesha.

Ngowuphi umahluko phakathi kweyeza leBiological kunye neBiosimilar elinye?

Iyeza le-Biosimilar alifani neyeza le-Biological, kodwa ulwakhiwo kunye nesenzo salo sisondele kakhulu kwiyeza lokuqala. Iyeza le-Biosimilar libiza ngaphantsi ngelixa lihlala lisondelelene kakhulu ne-Biologic yokuqala. Bobabini baya kuba nesenzo esifanayo kunye nokusetyenziswa. Zive ukhululekile ukuxoxa ngazo zombini iindlela kunye nogqirha wakho ukuba zikhona. 

Ngaba iyeza lebhayoloji lilungiselelwe mna?

Kubalulekile ukuvayisha izinto ezininzi xa ucinga ngamayeza ebhayoloji:

  • Loluphi unyango esele ndiluzamile?
  • Ngaba kufuneka ndiyitshintshe into endiyenzayo?
  • Ngaba ndikulungele ukutofwa rhoqo kwiofisi kagqirha wam?
  • Liza kubiza malini iyeza?

Kubalulekile ukuxoxa ngamayeza e-Biological kunye nogqirha wakho ukuze uqiniseke ukuba oku kulungile kuwe. Jonga iphepha lethu elithi "Xoxa" ukujonga izicwangciso ezisebenzayo zokuthetha nogqirha wakho malunga neyeza le-Biological.

funda

  • Ngawaphi amagama ekufuneka uyazi?
  • Ngawaphi amayeza ebhayoloji asetyenziselwa ukwaliwa kunye nemiba yempilo yomoya?
  • Ngaba amayeza ebhayoloji ayabiza?
  • Lunjani unyango ngamayeza ebhayoloji?
  • Yintoni ekufuneka ndiyithathele ingqalelo xa ndicinga ngamayeza ebhayoloji?
Funda ngakumbi>

Xoxa

  • Yeyiphi imibuzo endifuna ukuyibuza ugqirha wam okanye umboneleli wezempilo?
  • Yintoni ekwabelwana ngayo ukwenza izigqibo?
  • Ingaba ugqirha wam kunye nam ndindifumana njani iyeza leBiological elindifaneleyo?
Funda ngakumbi>

Thatha amanyathelo

  • Ndilulungiselela njani unyango ngamayeza e-Biological?
  • Zeziphi izibonelelo ezifumanekayo kum njengoko ndisiya phambili namayeza e-Biological?
  • Ndilindele ntoni kunyango ngamayeza ebhayoloji?
Funda ngakumbi>

Ngokusekelwe eVienna, e-Austria, iBhodi ye-GAAPP imele yonke imimandla yehlabathi kunye namaqela amakhulu namancinci, onke anenjongo efanayo: ukuxhobisa isigulane kunye nokuxhasa ilizwi lesigulane ukuze abenzi bezigqibo kumacandelo karhulumente kunye nabucala kurhulumente. yaye imizi-mveliso iya kunikela ingqalelo kwiimfuno zomonde, iminqweno yomonde namalungelo omonde.

Ukusukela ngo-2009 siye sakhula saba ngumbutho odlamkileyo wehlabathi lonke onamalungu angaphezu kwama-60 avela kwilizwekazi ngalinye esabelana ngolwazi kunye nezona nkqubo zilungileyo, iinkxalabo kunye namathemba.

Ayingomgaqo-nkqubo weGlobal Allergy & Airways Patient Platform ukucebisa okanye ukuxhasa nayiphi na imveliso okanye unyango.

Kuyinxalenye yendima ye-GAAPP ukunika ulwazi kuluhlu olubanzi lweemveliso kunye nonyango ukugcina abo baneengxaki zokwaliwa kunye nemiba yomoya benolwazi olupheleleyo kangangoko kuzo zonke iinketho ezikhoyo. Ukufumana iingcebiso zonyango, dibana nengcali yezempilo.

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