Amandongomane_Allergy

NgoJanuwari 2021 iKhomishini yaseYurophu yamkele unyango lokuqala lwe-peanut allergies.
Ukuqaliswa kwangoko eJamani nase-UK ngoMeyi 2021.

I-Aimmune Therapeutics 'IPALFORZIA®

IKhomishini yaseYurophu (EC) ivumile iPALFORZIA® [umgubo ocoliweyo IArachis hypogaea L., amadlozi (amandongomane)] kunyango lwe-peanut allergies, eyenza ukuba ibe lunyango lokuqala kule meko. Iveliswe ngu Unyango lweAimmune, I-PALFORZIA ibonakalisiwe kwizigulana ezineminyaka emine ukuya kwi-17 iminyaka ene-diagnostic eqinisekisiweyo ye-peanut allergy ngokudibeneyo nokutya okuthintela amandongomane kwaye ingaqhubeka kwizigulana ezineminyaka eli-18 ubudala nangaphezulu.

I-PALFORZIA sisiyobisi esintsonkothileyo se-biologic esisetyenziswe ngendlela efanelekileyo yokulinganisa eyakha kwinkulungwane yophando lwe-immunotherapy yomlomo (OIT). Nge-OIT, iiproteni ezithile ze-allergenic zifunxwe ekuqaleni ngamanani amancinci kakhulu, zilandelwa ngamanani anyukayo, oko kunokubangela ukubanakho ukunciphisa ukungahambelani komzimba kwi-allergen ekuhambeni kwexesha. I-PALFORZIA yi-OIT ye-pharmacy-grade ye-peanut allergies kunye neprofayili ye-allergen echazwe kakuhle ukuqinisekisa ukuhambelana kwethamo, ukusuka kwi-0.5mg (elinganayo ne-1 / 600th yamandongomane) ukuya kwi-300mg.

Ukwamkelwa bekusekwe kwiphakheji yedatha kubandakanya izilingo ezimbini ezibalulekileyo zesigaba se-III, iPALISADE kunye ne-ARTEMIS. Ulingo luvavanye unyango kubathathi-nxaxheba abangama-671 abane-peanut allergies eMntla Melika naseYurophu. Kuzo zombini ezi zifundo, unyango lwe-PALFORZIA lubangele ukonyuka okukhulu kwinani leprotini yamandongomane eyanyamezelwayo, xa kuthelekiswa ne-placebo. Abathathi-nxaxheba bafumana ixesha lokunyuka kwethamo lokuqala kwiiveki ezingama-20 ukuya kuma-40 eziqala kwi-3mg de kwafikelelwa idosi ye-300mg. Abathathi-nxaxheba emva koko bafumana iinyanga ezintandathu (PALISADE) okanye iinyanga ezintathu (i-ARTEMIS) yolondolozo lwe-immunotherapy nge-300mg PALFORZIA okanye i-placebo de kube sekupheleni kophononongo.

“Iziphumo zovavanyo lwezonyango lweSigaba sesi-III esibonakalisiweyo zibonise ngaphezulu kwesiqingatha sezigulana ezanyangwa nge-PALFORZIA zikwazile ukunyamezela ukulingana kweenkozo zamandongomane ezisixhenxe ukuya kwesibhozo emva kwenyanga ezilithoba zonyango. Olu lwazi lunyanzelayo luqaqambisa amandla alo okunciphisa ukungahambelani komzimba, kubandakanya i-anaphylaxis kwimeko yokuvezwa okungalindelekanga kwiproteni yamandongomane, utshilo uNjingalwazi uGeorge du Toit, umphandi ofunda ngezilingo zePALISADE kunye neARTEMIS.

Ukukhula

Ukuxhaphaka kwamandongomane utywala, eyona nto ixhaphakileyo ekutyeni ukutya ebantwaneni, iphindaphindwe kathathu kule minyaka ingama-2 idlulileyo. Namhlanje, ukuya kuthi ga kwiipesenti ezi-2.5 zabantwana abaye bafunyanwa benengxaki yamandongomane. Nangona kunjalo, ubukho bokwenyani bokungalungelelani kokutya abaziwa. Abo banembali yosapho yokungezwani komzimba, i-asthma, okanye i-eczema, banokuba semngciphekweni omkhulu.

Yenzeka njani iPeanut Allergy?

Ukunganyangeki kwamandongomane kwenzeka xa amajoni omzimba womntu ehluleka ukuqaphela iprotein yamandongomane kwaye egqithisela kuwo.

Izinto zofuzo kodwa nezinto ezisingqongileyo zinokuchaza ukungahambi komzimba.

Imbali yosapho, izehlo zokuqunjelwa, kunye nokuvezwa kweprotein yesoya zazinxulunyaniswa nokukhula kwamanqwanqwa ekukhuleni kwabantwana kwisifundo esinye, kodwa akukho mpendulo icacileyo malunga nokuba kutheni umntwana omnye efumana i-peanut allergies enye ingenayo.

Zithini iimpawu zoMdyarho we-Peanut?

Amandongomane aleji ahlala evela ebuntwaneni, kodwa ngokomgaqo anokuvela nangaliphi na ixesha. Iziphumo ezinzulu ngakumbi zihlala ziqala kwiminyaka yobudala.

Iziphumo zihlala ziqala kwangoko emva kokuvezwa kwamandongomane okanye iimveliso ezinamandongomane. Iimpawu zihlala ziqala kwimizuzu embalwa yokuvezwa kodwa zinokuhlala ukuya kwiiyure ezimbini.

Iimpawu zamanqatha:

  • Ukuphendula kwesikhumba njengokukhawuleza, urticaria okanye i-eczema
  • Iimpawu zesisu (GI) ezinje ngesicaphucaphu, iintlungu zesisu, ukugabha, okanye urhudo
  • Amehlo amanzi, ukukhohlela, okanye impumlo egobileyo

Ukusabela okunamandla

Ukutyiwa kwamandongomane kunokubangela iimpendulo ezisongela ubomi. Ezi mpendulo zinokwandulelwa lulusu, i-GI okanye iimpawu zokuphefumla eziphezulu, okanye zinokuqalisa ngesiquphe.

Iimpawu zokusongela ubomi bamandongomane okubangelwa:

  • Iimpawu eziphezulu zokuphefumla kubandakanya ukukhwehlela, okanye impumlo ebusayo
  • Ukugubha
  • Ukudumba, okwaziwa ngokuba yi-angioedema, yemilebe, ulwimi, ubuso, okanye umqala
  • Iziphumo ezinzima, ezibizwa ngokuba yiAnaphylaxis, zinokubakho, zibangele ukuba kube nobunzima, ukuphefumla nzima, okanye ukuphulukana nengqondo

Ukutya okutyiwa ngamandongomane kunokwenzeka ngakumbi kunezinye izinto ezibangela ukunganyangeki kokutya kubangela iAnaphylaxis. I-Anaphylaxis yimeko engxamisekileyo yezonyango efuna unyango kwangoko.

Uninzi lokusweleka okunxulumene nokutya okungafunekiyo kunxulunyaniswa nokufakwa kwamandongomane kunye neAnaphylaxis.

Imithombo: